00 This protocol describes a static compression test for evaluating the mechanical properties of 3D-printed scaffolds. Static compression test can be performed for 3D bioprinted hydrogel-based scaffolds using TA instruments. To mimic the physiological environment of the body, it is recommended to perform the compression test in a wet […]
Protocol for static compression testing of printed hydrogel scaffolds
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+10 Materials • Claro™ BG800 Bionk kit (REGEMAT 3D, RGMB025 – 027)* • 5 cc syringe (REGEMAT 3D, xxxx)* • Blue syringe tips (details) • Phosphate Buffer Saline (PBS) Equipment • Dual Tempered Syringe (REGEMAT 3D, XXXX)* • UV light tool (450 nm, REGEMAT 3D, XXXX) • BIO V1 or […]
+10 Polylactic acid (PLA) and polycaprolactone (PCL) are two of the most widely used materials in tissue engineering, due to their properties. PLA is known for its high rigidity, mechanical strength and biocompatibility, while PCL is valued for its flexibility, longer degradation time and excellent thermal processability. However, the use […]
+10 For info please contact Sara Román <lab4@regemat3d.com> PLA (polylactic acid) filaments enriched with hydroxyapatite exhibit ideal attributes for 3D printing bioactive scaffolds with applications in tissue engineering and bone regeneration. Hydroxyapatite, a key component of human bone tissue, imparts osteoconductive properties and enhances the biocompatibility of the scaffolds, […]
+30 INTRODUCTION Chitosan (CS) is a naturally derived semicrystalline polymer that is obtained by partial deacetylation of chitin under alkaline conditions [1]. It is one of the most widely used materials to prepare hydrogels due to its excellent biocompatibility, nontoxicity, and biodegradability [2]. Furthermore, it dissolves in dilute acids through […]
00 Introduction Collagen type I is the most common fibrillary collagen found in skin, bone, tendons and other connective tissues, accounting for around 90% of the body’s total collagen. Collagen type I-based hydrogels are ideal for 3D printing and bioprinting applications due to their excellent biocompatibility, biodegradability and controllable printability. […]
00 INTRODUCTION GEL-MA INX© is a gelatin-based bioink that exhibits excellent biomimicry given it derives from natural collagen, the main component of the extracellular matrix. GEL-MA INX© is based on the functionalisation of gelatin by covalent attachment of methacryloyl moieties to its amine groups, yielding gelatin-methacrylamide (GEL-MA). GEL-MA INX© is […]
00 INTRODUCTION Tissue engineering aims for assembling functional constructs that restore, maintain, or improve damaged tissues or whole organs. In the quest for the optimal tissue-engineered solution per specific application, the employment of gene expression analysis techniques is commonly desired. A pre-requisite for gene expression analysis is the isolation of […]
+10 INTRODUCTION Synthetic hydrogels are chemically defined animal component and pathogen-free hydrogels with tailored biological, mechanical and rheological properties for 3D bioprinting. Their synthetic origin avoid batch to batch variations, giving users the confidence to achieve reliable and consistent results with potential for clinical translation. Amongst the different options in […]
00 Introduction FlexdymTM is a block co-polymer belonging to the styrene-ethylene-butylene-styrene (SEBS) family of thermoplastic elastomers which is specifically tailored for the fabrication of microfluidic devices and flexible scaffolds for biomedical applications. The elastomeric nature enables its deformation even at high tensile strengths without fracture, making this material a suitable […]