+30 INTRODUCTION Type I collagen is the most abundant type of collagen in the human body, as a major structural matrix protein in skin and many other tissues including bone, tendon and fibrous connective tissues. ColBioink is a sterile solution of highly purified collagen type I from porcine origin that […]
Tissue
28 posts
+30 INTRODUCTION Hydrogels are at the forefront of 3D bioprinting and tissue engineering. However, the wide variety of choices available, and the diverse physicochemical nature of the biomaterials comprising the hydrogels, complicate the selection of the most adequate formulation for each specific application. The purpose of this method is to […]
+10 INTRODUCTION Collagen is the most abundant structural protein in the extracellular matrix (ECM), accounting for 30% of the total body protein content in humans. Amongst the 28 types of collagen that have been already identified, collagen type I is the most abundant by far, playing its most prominent functional […]
00 “Next generation gelatin-based bio-ink.” Introduction X EASYGEL INX© is a gelatin-based shear thinning, cell-interactive ECM mimicking ink. X EASYGEL INX combines all the benefits of conventional gelatin/gel-MA based inks in combination with a highly improved printing process thanks to its shear thinning behavior, as schematically presented in Figure 1a. […]
+30 Facilan™ PCL 100 Filament (MW = 50000 g/mol) was used as 3D printing filament. The scaffolds were designed with the software Regemat3D Designer v1.4.4 and printed using a Regemat3D Bio V1® bioprinter (REG4Life, REGEMAT 3D, Granada, Spain) equipped with a glass bed and a 0.4 mm diameter nozzle. The […]
+30 The printing process of FILAMENT-Oss is carried out by a Fused Filament Fabrication process (FFF/FDM). As any other Additive Manufacturing technique, the FFF creates a physical 3D object from a digital model (usually a CAD representation) which is sliced in layers at consecutive height levels. The process requires of […]
+20 Introduction Liposomes are spherical vesicles consisting of one or more concentric phospholipid bilayers enclosing an aqueous core. Nontoxic and biodegradable liposomes are useful tools to package both hydrophilic and hydrophobic biomolecules (including therapeutic agents) that may be further incorporated into target cells to elicit functional changes. Extensive research is […]
+5-1 The biofabrication technique comprises two processes for every volume: first, the fused deposition of the thermoplastic polymer to obtain the scaffold and second, the injection of the bioink and CaCl2 solution to fill the printed scaffold. Firstly, commercial non-medical grade PLA (1.75 mm filament) was used and it […]
+100 Introduction: Injuries to the knee meniscus commonly lead to osteoarthritis. Current therapies for meniscus regeneration, including meniscectomies and scaffold implantation, do not achieve complete functional tissue regeneration. This has led to increased interest in cell and gene therapies and tissue engineering approaches to meniscus regeneration. The implantation of a […]
+40 Introduction Hypoxia is a common characteristic of many solid tumors that has been associated with tumor aggressiveness. Limited diffusion of oxygen generates a gradient of oxygen availability from the blood vessel to the interstitial space and may underlie the recruitment of macrophages fostering cancer progression. However, the available data […]