Hydroxypropyl methylcellulose METHOCEL ™ K4M (Colorcon Ltd., UK) was used as hydrophilic polymer to prepare drug-loaded hydrogels for IVF. Anhydrous theophylline (Acofarma, Spain) has been used as a model drug.
HPMC (1% w/v) gel was prepared by adding powdered HPMC into 100 ml of hot water (90 °C) and thoroughly agitating until a dispersion was formed. The dispersion was cooled with ice and stored in a refrigerator for 24 h until a smooth homogenous gel, free from air bubbles and aggregates, was formed. Volumes of HPMC gel and ethanol at a ratio of 25:75 (v/v) were thoroughly mixed to form a hydro-alcoholic gel. Finally, theophylline was added until complete dissolution (20 mg/ml).
Reference: V. Linares, M. Casas, I. Caraballo, Printfills: 3D printed systems combining fused deposition modeling and injection volume filling. Application to colon-specific drug delivery, Eur. J. Pharm. Biopharm., 134 (2019) 138-143.
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